Divergence Labs is an evergreen research engine for new medicines.

We are a collective of drug hunters, computer scientists, biologists, and hardware builders systematizing the exploration, identification, and solution of complex biological questions.

HIGH-VELOCITY SCIENTIFIC DISCOVERY

Ideas

// IDEAS

We explore areas historically constrained by molecular engineering. Our R&D Committee, collectively responsible for 30+ FDA approvals, then selects the highest impact problems.

Exploration

// TECHNOLOGY

To find previously inaccessible solutions, we build and deploy proprietary hardware, computational models, and biological tools to eliminate constraints.

Lab Environment

// ACTION

We provide the freedom and flexibility for our drug hunters to focus entirely on translating insights into new medicines. No grant-writing or big pharma bureaucracy.

We believe systematic principles for discovering great medicines exist.

Success in drug discovery is often random and unpredictable. By bringing together divergent insights, proprietary experimental techniques, computational modeling, and career drug hunters, we seek repeatable methods for designing medicines for any disease.

Example Strategy

Molecular Surface Engineering

// The Opportunity

Existing treatments can be associated with liabilities. We believe this is often due to a lack of precision in molecular engineering and is a persistent opportunity to design better medicines.

Molecular Surface Engineering Strategy
// MOLECULAR SURFACE ENGINEERING

The Insight

Conventional discovery tools yield molecules binding targets in the wrong region, sometimes resulting in clinical toxicity or suboptimal efficacy. Changing the surface of a molecular interaction could lead to greater efficacy or safety.

Our Approach

Our team of M.D. and Ph.D-level researchers find these issues, then deploy our discovery capabilities to identify alternate functional surfaces, direct molecules towards them with high precision, and validate their effect.

// MULTIPLE STRATEGIES. ONE FOCUS.

Across all areas of biology, we have one focus: developing the most compelling new medicines for patients who need them.

// Surface Engineering

Altering protein interactions to drive greater benefit.

// Molecular Mimicry

Unlocking biology constrained by manufacturing and half-life.

// Therapeutic Window

Increasing threshold by which potential toxicities could occur.

// Bioavailability

Enhancing the concentration at the desired tissue.

We pursue treatments for any disease with potential for great impact.

Systematic opportunities are not constrained to one disease or area of biology, so Divergence isn't either. Our platform allows us to build and develop product candidates across all areas of medicine.

// ACTIVE PROGRAMS
DL201
Geographic Atrophy
Ophthalmology
Discovery
Preclinical
Proof of Concept
Registrational
DL202
Macular Telangiectasia
Ophthalmology
Discovery
Preclinical
Proof of Concept
Registrational
DL203
Glaucoma
Ophthalmology
Discovery
Preclinical
Proof of Concept
Registrational
UNDISCLOSED
Atopic Dermatitis
Immunology
// COMPLETING PROGRAM NOMINATION...
// OUR TEAMS ARE CONSTANTLY EVALUATING NEW OPPORTUNITIES ACROSS ALL THERAPEUTIC AREAS, FROM HEART DISEASE TO NEUROSCIENCE.

We are a unified collective of interdisciplinary thinkers.

Our team is made up of drug hunters, hardware engineers, and computational biologists. We operate without silos, united by a culture of intellectual honesty and the relentless pursuit of high-value medicines.

Our Operating System

CULTURE

Built on intellectual honesty and a relentless commitment to excellence.

Intellectual HonestyWe admit when we're wrong, advocate when we're right, and crave constructive feedback.
Bias for ActionWe take initiative, seek new ideas, and take well-researched, smart risks.
Team FirstWe win and lose as a team. No egos. Great ideas come from anywhere.
Independence of ThoughtWe challenge consensus and aren't afraid to "zig while others zag."
ResilienceDrug development is a tough sport. We persevere in the face of challenge.
Embrace the UnfamiliarWe are humbled and excited by how much there is left to learn.

PROCESS

Developed through experimentation, iteration, and ambition to succeed.

Focus on MilestonesWe work backwards from long-term objectives, tracking detailed goals every six weeks.
Get Better Every DayUncommon results require uncommon effort. We treat every day as an opportunity to win.
Support Your TeammatesWe push each other to succeed and pick each other up when we fall short.
Embrace ChangeWhen data doesn't support our hypothesis, we reject our prior views and pivot immediately.
Roll with the PunchesWe will fail and "get punched in the face." The most important thing is that we keep fighting.

Push yourself and your teammates to build the future.

We are looking for the obsessive, the curious, and the eclectic. Whether you are an ML researcher bored by ad-tech, an academic tired of grant writing, or an investor seeking to have greater impact on society, Divergence is built to be the best place in the world to solve hard problems that matter.

Areas of Impact

Discovery Strategy & Capital Allocation

Pursue your passion for idea generation, capital allocation, and risk management to build and manage our portfolio of high-value medicines.

Engineering & Molecular Biology

Work to solve challenging biological and technical problems, designing new systems and methods to enable discovery of molecules with precision, scale, and speed.

Computational Biology & ML

Create new statistical models for molecular structure, interaction, and biological activity to enhance Divergence's ability to solve medicine's most valuable problems.

Nonclinical & Clinical Development

Translate breakthrough science into real medicines, driving programs through regulatory milestones following precision medicine principles.

Opportunities at Every Level

// Graduate Students

Since inception, we train current M.D., Ph.D. and M.D./Ph.D. students through Visiting Scientist and Investment Fellowship programs at leading Universities. Our Fellows include a diverse array of researchers who have done everything from pioneer molecular docking models to study mosquito behavior in the Cayman Islands and spend time playing poker professionally.

// Experienced Researchers

As a Scientist here, we provide the technical tools and professional environment to help you succeed and grow through mentorship, progressive project leadership, and opportunities for advancement. Our flat structure and interdisciplinary team allows Scientists to impact the entire organization beyond the wet and dry labs.

// Investment Analysts

Our Investment Analyst program takes individuals with a demonstrated passion for distilling R&D to its fundamental elements of risk, reward, and the path to success, and teaches them to generate hypotheses, distill into high-impact opportunities, and operationalize their discovery and development.

// Chief Scientific & Medical Officers

For career drug hunters, we offer an opportunity to build an exceptional business inside of Divergence Labs. We equip you with market research, molecular engineering, regulatory, and manufacturing expertise to get the best out of your drug development process.

// JOIN US

We are actively building our teams across San Francisco, Boston, New York, and Cambridge, UK. Reach out to our team to learn more.

[email protected]
Divergence Labs Location